Search results for "Migraine disorders."

showing 10 items of 106 documents

Triptans and CGRP blockade - impact on the cranial vasculature.

2017

Abstract The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide (CGRP), which modulate pain transmission and vascular tone. Thirty years after discovery of agonists for serotonin 5-HT1B and 5-HT1D receptors (triptans) and less than fifteen after the proof of concept of the gepant class of CGRP receptor antagonists, we are still a long way from understanding their precise site and mode of action in migraine. The effect on cranial vasculature is relevant, because all specific anti-migraine drugs and mig…

0301 basic medicineMigraine DisordersCalcitonin gene related peptide – CGRPNeuropeptidelcsh:MedicineMigraine modelsReviewTriptansReview ArticleCalcitonin gene-related peptide03 medical and health sciences0302 clinical medicineJournal ArticlemedicineHumansMigraine treatmentReceptorbusiness.industryTriptans Calcitonin gene related peptide – CGRP Anti-CGRP (receptor) monoclonal antibodies – mAbs Middle meningeal artery Middle cerebral arteries Migraine models Magnetic resonance angiography (MRA)Anti-CGRP (receptor) monoclonal antibodies – mAbsTrigeminovascular systemlcsh:RTriptansGeneral MedicineMiddle meningeal arterymedicine.diseaseTryptamines3. Good healthMagnetic resonance angiography (MRA)Middle cerebral arteries030104 developmental biologyAnesthesiology and Pain MedicineMigraineAnesthesiaNeurology (clinical)SerotoninbusinessNeuroscience030217 neurology & neurosurgerymedicine.drugReceptors Calcitonin Gene-Related PeptideThe journal of headache and pain
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PACAP38 and PAC1 receptor blockade: a new target for headache?

2018

Abstract Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent inducer of migraine-like attacks, but the mechanism behind this has not been fully elucidated. Migraine is a neurovascular disorder, recognized as the second most disabling disease. Nevertheless, the antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor are the only prophylactic treatment developed specifically for migraine. These antibodies have displayed positive results in clinical trials, but are not effective for all patients; therefore, new pharmacol…

0301 basic medicineSide effectPAC1 receptorMigraine DisordersMigraine Disorders/drug therapylcsh:MedicinePituitary Adenylate Cyclase-Activating Polypeptide/antagonists & inhibitorsReview ArticleTriptansPharmacologyCalcitonin gene-related peptidePACAPNeuroprotectionmigraine; PAC1 receptor; PACAP; prophylactic treatment; animals; disease models animal; headache; humans; migraine disorders; pituitary adenylate cyclase-activating polypeptide; receptors pituitary adenylate cyclase-activating polypeptide type I; neurology (clinical); anesthesiology and pain medicine03 medical and health sciences0302 clinical medicineAnimalsHumansMedicineMigraine treatmentReceptorMigraineHeadache/drug therapybusiness.industrylcsh:RHeadacheGeneral Medicinemedicine.disease3. Good healthBlockadeDisease Models Animal030104 developmental biologyAnesthesiology and Pain MedicineMigrainePituitary Adenylate Cyclase-Activating PolypeptideNeurology (clinical)businessProphylactic treatment030217 neurology & neurosurgeryReceptors Pituitary Adenylate Cyclase-Activating Polypeptide Type IReceptors Pituitary Adenylate Cyclase-Activating Polypeptide Type I/antagonists & inhibitorsmedicine.drugJournal of Headache and Pain
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Hyperresponsivity in migraine: a network dysfunction or an analytic cognitive style-connected feature?

2018

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0301 basic medicinemedicine.medical_specialtyNeurologyMigraine DisordersDermatologyThinking03 medical and health sciencesCognition0302 clinical medicinemedicineHumansNeuroradiologyGeneral Medicinemedicine.diseasePsychiatry and Mental health030104 developmental biologyMigraineFeature (computer vision)Neurology (clinical)NeurosurgeryPsychology030217 neurology & neurosurgeryPersonality2708Cognitive psychologyCognitive styleNeurological Sciences
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Blocking CGRP in migraine patients – a review of pros and cons

2017

Abstract Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than migraine such as hypertension, depression and epilepsy. During the last decade, however, blocking calcitonin gene-related peptide (CGRP) has emerged as a possible mechanism for prevention of migraine attacks. CGRP has been shown to be released during migraine attacks and it may play a causative role in induction of migraine attacks. Here, we review the pros and cons of blocking CGRP in migraine patients. To date, two different classes of drugs blocking CGRP have been developed: …

0301 basic medicinemedicine.medical_specialtyanesthesiology and pain medicineNeurologyCalcitonin Gene-Related PeptideMigraine DisordersCentral nervous systemlcsh:MedicineNeurological disorderReview ArticleCalcitonin gene-related peptidePlaceboBioinformatics03 medical and health sciencesEpilepsy0302 clinical medicineCalcitonin Gene-Related Peptide Receptor AntagonistsMedicineAnimalsHumansMigraineneurology (clinical)integumentary systembusiness.industrylcsh:Racute treatment; CGRP; CGRP receptor; gepants; migraine; prophylactic treatment; neurology (clinical); anesthesiology and pain medicineCgrp receptorGeneral MedicineGepantsmedicine.disease3. Good health030104 developmental biologymedicine.anatomical_structureMigrainenervous systemAnesthesiaAcute treatment; Cgrp; Cgrp receptor; Gepants; Migraine; Prophylactic treatment; Neurology (clinical); Anesthesiology and Pain MedicineCgrpAnimal studiesbusinessGepantProphylactic treatmentAcute treatment030217 neurology & neurosurgery
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Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation.

2021

Introduction: Episodic migraine is a debilitating condition associated with vast impairments of health, daily living, and life quality. Several prophylactic treatments exist, having a moderate ratio of action related to side effects and therapy costs. Repetitive transcranial magnetic stimulation (rTMS) is an evidence based therapy in several neuropsychiatric conditions, showing robust efficacy in alleviating specific symptoms. However, its efficacy in migraine disorders is unequivocal and might be tightly linked to the applied rTMS protocol. We hypothesized that multifocal rTMS paradigm could improve clinical outcomes in patients with episodic migraine by reducing the number of migraine day…

AdultAuramedicine.medical_treatmentMigraine Disorders50% responder RatesBiophysicsStimulationNeurosciences. Biological psychiatry. NeuropsychiatryPilot Projectslaw.inventionRandomized controlled trialDouble-Blind MethodlawmedicineHumansAdverse effectMigraineBalance (ability)business.industryGeneral NeurosciencePreventionMiddle Agedmedicine.diseaseTranscranial Magnetic StimulationTranscranial magnetic stimulationMultifocal rTMSTreatment OutcomeMigraineAnesthesiaPropensity score matchingMigraine daysQuality of LifeFemaleNeurology (clinical)businessRC321-571Brain stimulation
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The impact of a worksite migraine intervention program on work productivity, productivity costs, and non-workplace impairment among Spanish postal se…

2004

Migraine is associated with a significant productivity loss to employers, who may benefit from making a migraine intervention available to their employees.To evaluate changes in migraine-related productivity and non-workplace impairment associated with a migraine intervention program from the employer perspective.This was a pre-test post-test study of Spanish Postal Service employees with migraine. The intervention consisted of counseling from occupational health physicians and rizatriptan 10 mg for symptomatic treatment of two subsequent migraine headaches. Physicians also prescribed additional medications for migraine prophylaxis, treatment of tension headaches, and rescue medications. Mi…

AdultCounselingMalemedicine.medical_specialtyMigraine DisordersMEDLINEOccupational Health ServicesEfficiencyOccupational safety and healthIntervention (counseling)AbsenteeismmedicineHumansPostal ServicePsychiatryProductivitybusiness.industryGeneral MedicineTriazolesmedicine.diseaseRizatriptanTryptaminesSerotonin Receptor AgonistsMigraineSpainAbsenteeismCosts and Cost AnalysisFemaleHeadachesmedicine.symptombusinessmedicine.drugFollow-Up StudiesCurrent medical research and opinion
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Sound-Induced Flash Illusions Support Cortex Hyperexcitability in Fibromyalgia

2022

Objectives. Fibromyalgia (FM) is characterized by spontaneous chronic widespread pain in combination with hyperalgesia to pressure stimuli. Sound-induced flash illusions (SIFIs) reflect cross-modal interactions between senses allowing to assess a visual cortical hoerexcitability (VCH) by evaluating the fission and fusion illusions disruption. The aims of the present study were to explore whether SIFIs are perceived differently in patients with fibromyalgia as compared to healthy controls (HCs) and how migraine affects fission and fusion illusions in fibromyalgia. Methods. A single flash (F) accompanied by 0 to 4 beeps (B) was presented to induce the fission illusion while multiple flash (i.…

AdultFibromyalgiaArticle SubjectMigraine DisordersInfant NewbornAnxietyMiddle AgedIllusionsAnesthesiology and Pain MedicineNeurologyIllusionMigraine DisorderAcoustic StimulationAuditory PerceptionHumansSettore MED/26 - NeurologiaFemalePhotic StimulationHumanPain Research and Management
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Cyclical changes of cortical excitability and metaplasticity in migraine: evidence from a repetitive transcranial magnetic stimulation study.

2013

The primary brain dysfunctions leading to the onset of a migraine attack remain largely unknown. Other important open questions concern the mechanisms of initiation, continuation, and termination of migraine pain, and the changes in brain function underlying migraine transformation. Brief trains of high-frequency repetitive transcranial magnetic stimulation (rTMS), when applied to the primary motor cortex at suprathreshold intensity (⩾120% of resting motor threshold [RMT]), elicit in healthy subjects a progressive, glutamate-dependent facilitation of the motor evoked potentials (MEP). Conversely, in conditions of increased cortical excitability, the rTMS trains induce inhibitory MEP respons…

AdultMaleAdolescentHeadache Homeostatic plasticity Magnetic stimulation Migraine pathogenesis Migraine with aura Motor cortexmedicine.medical_treatmentMigraine DisordersYoung AdultChronic MigrainemedicineHumansIctalAgedNeuronal PlasticityElectromyographyMotor CortexMiddle Agedmedicine.diseaseTranscranial Magnetic StimulationMigraine with auraTranscranial magnetic stimulationAnesthesiology and Pain Medicinemedicine.anatomical_structureNeurologyMigraineCortical spreading depressionFemaleNeurology (clinical)Primary motor cortexmedicine.symptomPsychologyNeuroscienceMotor cortexPainReferences
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Types of Triggers in Migraine - Factor Structure of the Headache Triggers Sensitivity and Avoidance Questionnaire and Development of a New Short Form…

2020

OBJECTIVE: To examine the factor structure of the Headache Triggers Sensitivity and Avoidance Questionnaire (HTSAQ) and its German version (HTSAQ-G), in order to identify potential different types of triggers. Furthermore, a short form of the questionnaire was developed. BACKGROUND: The HTSAQ includes 24 of the most commonly reported headache triggers (eg, stress, odors, lack of sleep). Both the HTSAQ and HTSAQ-G appeared to be reliable and valid measures of sensitivity to and avoidance of headache triggers. METHODS: In a cross-country collaboration, data from 2 cross-sectional studies including N = 391 individuals diagnosed with migraine from Australia (n = 222) and Germany (n = 169) were …

AdultMaleCoping (psychology)AdolescentPsychometricsMigraine DisordersFactor structure03 medical and health sciencesYoung Adult0302 clinical medicineChronic MigraineCronbach's alphaGermanymedicineHumans030212 general & internal medicineAgedAged 80 and overbusiness.industryCluster headacheAustraliaMiddle Agedmedicine.diseaseConfirmatory factor analysisClinical PracticeCross-Sectional StudiesNeurologyMigraineFemaleNeurology (clinical)businessFactor Analysis Statistical030217 neurology & neurosurgeryClinical psychologyHeadacheReferences
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Managing of Migraine in the Workplaces: Knowledge, Attitudes and Practices of Italian Occupational Physicians.

2022

Background and Objectives: Migraine is a debilitating disorder, whose incidence peak in the age group of 30–39 years overlaps with the peak of employment years, potentially representing a significant issue for occupational physicians (OP). The present study was performed in order to characterize their knowledge, attitudes and practices on migraine in the workplaces. Materials and Methods: A convenience sample of 242 Italian OP (mean age 47.8 ± 8.8 years, males 67.4%) participated in an internet-based survey by completing a structured questionnaire. Results: Adequate general knowledge of migraine was found in the majority of participants. Migraine was identified as a common and …

AdultMaleHealth Knowledge Attitudes Practiceattitudes job knowledge migraine occupation practicesmigraine; job; occupation; knowledge; attitudes; practicesHealth PersonnelMigraine DisordersPhysiciansHumansGeneral MedicineMiddle AgedWorkplaceMedicina (Kaunas, Lithuania)
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